Diverse actions of estradiol on anorexigenic and orexigenic hypothalamic arcuate neurons
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Nicotine excites hypothalamic arcuate anorexigenic proopiomelanocortin neurons and orexigenic neuropeptide Y neurons: similarities and differences.
Two of the biggest health problems facing us today are addiction to nicotine and the increased prevalence of obesity. Interestingly, nicotine attenuates obesity, but the underlying mechanism is not clear. Here we address the hypothesis that if weight-reducing actions of nicotine are mediated by anorexigenic proopiomelanocortin (POMC) neurons of the hypothalamic arcuate nucleus, nicotine should ...
متن کاملNicotine excites hypothalamic arcuate anorexigenic 3 proopiomelanocortin neurons and orexigenic neuropeptide Y 4 neurons : similarities and differences 5 6
24 Two of the biggest health problems facing us today are addiction to nicotine, and 25 the increased prevalence of obesity. Interestingly, nicotine attenuates obesity, but the 26 underlying mechanism is not clear. Here we address the hypothesis that if weight27 reducing actions of nicotine are mediated by anorexigenic POMC neurons of the 28 hypothalamic arcuate nucleus, nicotine should excite ...
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The hormone ghrelin stimulates eating and helps maintain blood glucose upon caloric restriction. While previous studies have demonstrated that hypothalamic arcuate AgRP neurons are targets of ghrelin, the overall relevance of ghrelin signaling within intact AgRP neurons is unclear. Here, we tested the functional significance of ghrelin action on AgRP neurons using a new, tamoxifen-inducible AgR...
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Hypothalamic neurons of the arcuate nucleus control food intake, releasing orexigenic and anorexigenic neuropeptides in response to changes in glucose concentration. Several studies have suggested that the glucosensing mechanism is governed by a metabolic interaction between neurons and glial cells via lactate flux through monocarboxylate transporters (MCTs). Hypothalamic glial cells (tanycytes...
متن کاملAppropriate inhibition of orexigenic hypothalamic arcuate nucleus neurons independently of leptin receptor/STAT3 signaling.
Leptin directly suppresses the activity of orexigenic neurons in the hypothalamic arcuate nucleus (ARC). We examined c-Fos-like immunoreactivity (CFLIR) as a marker of ARC neuronal activity in db/db mice devoid of the signaling form of the leptin receptor (LRb) and s/s mice that express LRb(S1138) [which is defective for STAT3 (signal transducer and activator of transcription) signaling]. Both ...
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ژورنال
عنوان ژورنال: Hormones and Behavior
سال: 2018
ISSN: 0018-506X
DOI: 10.1016/j.yhbeh.2018.04.001